Structural polymorphism of ex-vivo ALECT2 amyloid fibrils revealed by cryo-EM
Shumaila Afrin, Binh An Nguyen, Virender Pratap Singh, Preeti Singh, Parker T. Bassett, Maja Pękała, Bret M. Evers, Christian López, Yasmin Ahmed, Li Li, Raja Reddy Kallem, Andrew S. Lemoff, Christos Argyropoulos, Barbara Kluve‐Beckerman, Lorena Saelices
This study uses cryo-EM to reveal structural polymorphism in ex-vivo ALECT2 amyloid fibrils, identifying three morphologies and acetylation sites.
Nature Communications · Apr 11, 2026Peer-reviewedBiophysics