Author

Juan Francisco Codocedo

Indiana University IndianapolisORCID 0000-0002-9683-2156Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:statistical model· 1

Frequent Co-Authors

Claudia Mera-ReinaiD· 2 shared Cristian A. Lasagna‐ReevesiD· 2 shared Gary E. LandrethiD· 2 shared Brad T. CasaliiD· 1 shared Jack Scott· 1 shared Nur JuryiD· 1 shared Pablo MartíneziD· 1 shared Paul B. FalleniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Claudia Mera-ReinaORCID

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2 papers

Recent·Most cited

Therapeutic Targeting of Microglial Hexokinase-2 Recalibrates Inflammasome Activation and Improves Functional Recovery After Traumatic Brain Injury

Claudia Mera-Reina, Juan Francisco Codocedo, Paul B. Fallen, Jack Scott, Cristian A. Lasagna‐Reeves, Gary E. Landreth

bioRxiv · Mar 3, 2026 · PreprintNeuroscience

Therapeutic targeting of immunometabolism in Alzheimers disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progression.

Juan Francisco Codocedo, Claudia Mera-Reina, Peter Bor‐Chian Lin, Shweta S. Puntambekar, Brad T. Casali, Nur Jury, Pablo Martínez, Cristian A. Lasagna‐Reeves, Gary E. Landreth

This study shows that reducing Hexokinase 2 (HK2) in microglia slows Alzheimer's disease progression, but complete loss worsens inflammation, suggesting a complex role for HK2 in neuroinflammation.

bioRxiv · Nov 11, 2023 · PreprintNeuroscience