Author

Brad T. Casali

Indiana University School of MedicineORCID 0000-0001-9328-9728Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Gary E. LandrethiD· 2 shared Peter Bor‐Chian LiniD· 2 shared Adrian L. OblakiD· 1 shared Andy Po‐Yi TsaiiD· 1 shared Bruce T. LambiD· 1 shared Chuanpeng DongiD· 1 shared Claudia Mera-ReinaiD· 1 shared Cristian A. Lasagna‐ReevesiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Gary E. LandrethORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 25, 2026

Sex Chromosomes and Gonadal Hormones Contribute to B Cell Antibody Responses in Aging and Alzheimer's Disease

Hannah T. Zuppe, Brad T. Casali, Erin G. Reed-Geaghan

The paper investigates sex chromosome and gonadal hormone effects on B cell antibody responses in aging and Alzheimer's Disease using mouse models.

DOI 10.64898/2026.08.21.746231

mousebulk RNA-seq

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NeurosciencebioRxivPreprintNov 11, 2023

Therapeutic targeting of immunometabolism in Alzheimers disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progression.

Juan Francisco Codocedo, Claudia Mera-Reina, Peter Bor‐Chian Lin…·Gary E. Landreth

This study shows that reducing Hexokinase 2 (HK2) in microglia slows Alzheimer's disease progression, but complete loss worsens inflammation, suggesting a complex role for HK2 in neuroinflammation.

5 citations

mousebulk RNA-seq

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NeuroscienceNeurobiology of DiseasePeer-reviewedFeb 22, 2021

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia

Andy Po‐Yi Tsai, Peter Bor‐Chian Lin, Chuanpeng Dong…·Kwangsik T. Nho

This study shows INPP5D expression increases in Alzheimer's disease, particularly in plaque-associated microglia, and suggests it may be a risk factor and therapeutic target.

104 citationstop 1%

humanbulk RNA-seq

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