Declan Patrick McKernan

This study uses vascularised cerebral organoids treated with atorvastatin to model intracerebral haemorrhage and assess tissue injury and immune response.

This paper reviews and quantitatively analyzes studies on helminth-derived immunomodulatory proteins in animal models of inflammatory diseases, finding they reduce disease severity by modulating cytokine levels.

This review evaluates helminth-derived peptides' effects on inflammation in cellular models, finding they reduce pro-inflammatory cytokines and increase anti-inflammatory ones, suggesting therapeutic potential.

This study identifies transcriptomic changes in mouse hippocampus due to social isolation and links them to human genetic risk factors for neurodevelopmental disorders.

The paper identifies MEF2C direct target genes enriched for schizophrenia and cognitive function genes, showing their involvement in neurogenesis and mitochondrial function.