Siobhan Crilly

This study uses vascularised cerebral organoids treated with atorvastatin to model intracerebral haemorrhage and assess tissue injury and immune response.

Embedding day-8 cerebral organoids in Geltrex loaded with human brain microvascular endothelial cells, plus VEGF-supplemented mixed media, yields integrated endothelial networks and almost three-fold less apoptosis.

The paper shows that 25-hydroxycholesterol disrupts brain endothelial function by altering cholesterol metabolism, linking viral infection to brain vessel dysfunction in intracerebral haemorrhage.

The paper identifies a novel base-pairing interaction in the U8 snoRNA that underlies a Mendelian form of cerebral small vessel disease by analyzing zebrafish models and patient fibroblasts.