Xiao Zhang

Reinforcement learning with evolutionary priors unlocks multi-site enzyme optimization from sparse experimental feedback

AlphaVariant uses reinforcement learning with evolutionary priors to optimize enzyme variants from sparse experimental data, achieving high activity improvements in multiple rounds of optimization.

Ecological genomics of a novel host-parasitoid arms-race in nature

The paper studies genomic signatures of coevolution between a parasitoid fly and its cricket host, revealing arms-race dynamics and selective sweeps driven by host adaptations.

Vegetation change and functional composition shifts in southwestern China during late MIS 3 to LGM

This study examines vegetation and functional composition changes in southwestern China during the late MIS3 to LGM using pollen records, revealing shifts in forest types and functional traits driven by climate change.

Spatiotemporally distinctive astrocytic and neuronal responses to repetitive intracortical microstimulation

This study shows that astrocytes and neurons respond differently to intracortical microstimulation, with astrocytes showing spatially heterogeneous and temporally variable responses.

Rapid vegetation reorganization in Hengduan Mountains driven by high climatic oscillations

This study uses a high-resolution palynological record from Erhai Lake to show that Hengduan Mountains vegetation reorganized rapidly in response to climatic oscillations over 35,200 years, with future projections under high-emission scenarios indicating intensified reorganizations.

Impaired Calcium Signaling in Precapillary Sphincters and Pericytes Perturbs Neurovascular Regulation after an Ischemic Stroke

This study investigates how impaired calcium signaling in precapillary sphincters and pericytes contributes to neurovascular uncoupling after ischemic stroke in mice.

Using machine learning to overcome mosquito collections missing data for malaria modeling

The paper uses machine learning to impute missing mosquito data and improve malaria incidence predictions in Bolivar State, Venezuela, but finds it ineffective for P. falciparum.

An atlas of genetic effects on the monocyte methylome across European and African populations

The paper constructs a multi-ancestry methylome atlas of purified monocytes, identifies population-specific methylation quantitative trait loci, and performs methylome-wide association studies for 41 traits, revealing novel associations for type 2 diabetes.

ViFIT-assisted Histopathology: From H&E Style Standardization to Virtual Fiber Image Transformation

ViFIT-assisted histopathology converts diverse H&E-stained images into standardized H&E images and generates virtual fiber images, improving diagnostic workflows across cancer types.

Molecular logic of pheromone recognition enables rational design of insect behavior modulators

This paper decodes the structural logic of pheromone recognition in silkmoths to design small molecules that disrupt insect mating behavior.

Spatially mismatched cerebral blood flow and neuronal activity by intracortical microstimulation

This study investigates the spatial and temporal mismatch between neuronal activity and blood flow responses to intracortical microstimulation in mice, finding that low intensity stimulation preserves neurovascular coupling while high intensity causes mismatched responses and potential ischemia.

Multi-View Integrative Approach For Imputing Short-Chain Fatty Acids and Identifying Key factors predicting Blood SCFA

The paper develops M2AE, a multi-task multi-view model to impute blood SCFA levels using gut metagenomic data, dietary features, and host characteristics, showing improved performance over existing methods.

The neurovascular coupling response of the aged brain is brain-state dependent.

This study shows that neurovascular coupling in aged mice is slower and prolonged, with reduced Ca2+ signaling in vascular mural cells, and correlates with decreased spontaneous locomotion.