PROTEOME-SCALE RECOMBINANT STANDARDS AND A ROBUST HIGH-SPEED SEARCH ENGINE TO ADVANCE CROSS-LINKING MS-BASED INTERACTOMICS
Milan Avila Clasen, Max Ruwolt, Cong Wang, Julia Ruta, Boris Bogdanow, Louise Ulrich Kurt, Zehong Zhang, Shuai Wang, Fabio Cesar Gozzo, Tao Chen, Paulo C. Carvalho, Diogo Borges Lima, Fan Liu
The paper develops recombinant protein standards and a search engine for XL-MS, showing Scout outperforms existing tools in speed, sensitivity, and false-discovery rate control.
Nature Methods · Oct 31, 2024Peer-reviewedBioinformatics