Wai‐Yee Chan

This study uses human organoids to show that PTEN suppresses retinoic acid signaling to drive mesendoderm specification.

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

This study shows that SSH2 is essential for acrosome biogenesis and male fertility in mice by regulating actin remodeling through COFILIN.

The paper uses single-cell RNA sequencing to analyze microglial transcriptomic diversity in subarachnoid hemorrhage, identifying distinct subgroups and their roles in neuroinflammation.

The paper analyzes transcriptome and methylome data from mouse oocytes to understand aging and maturation, identifying biomarkers and a predictive model for oocyte quality.

The paper identifies spatiotemporal-specific small RNAs during hPSC differentiation using NMTSI and ASI, and provides a web tool for accessing results.

This study uses single-cell RNA sequencing to analyze spermatogonial stem cell establishment in mice, identifying key molecular transitions and novel markers.