Wuming Wang

Vascularized Organoids Emerge from a Heart-Foregut-like Intermediate Recapitulating Early Human Development

This study shows that heart/foregut-like structures form from human pluripotent stem cells, developing into vascularized cardiac organoids with multiple cell types.

Human Organoids Reveal PTEN-driven Mesendoderm Specification via Retinoic Acid Signaling Suppression

This study uses human organoids to show that PTEN suppresses retinoic acid signaling to drive mesendoderm specification.

Lipid Metabolism Remodeling in Human Cardiomyocyte Differentiation and Maturation

This study maps dynamic lipid changes during human cardiomyocyte differentiation using lipidomics and transcriptomics, identifying key lipid species and their roles in cardiac development.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.