Author

Marlene Jara

Instituut voor Tropische GeneeskundeORCID 0000-0002-9739-3589Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Hideo ImamuraiD· 2 shared Ilse Maes· 2 shared Jean‐Claude DujardiniD· 2 shared Achim C. SchnauferiD· 1 shared Alejandro Llanos‐CuentasiD· 1 shared Clément RegnaultiD· 1 shared David Mateus· 1 shared Elisa CupolilloiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBioinformatics

Hideo ImamuraORCID

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2 papers

Recent·Most cited

Transcriptional shift and metabolic adaptations during Leishmania quiescence using stationary-phase and drug pressure as models

Marlene Jara, Michael Peter Barrett, Ilse Maes, Clément Regnault, Hideo Imamura, Malgorzata A. Domagalska, Jean‐Claude Dujardin

The paper quantifies transcriptome and metabolome changes in Leishmania during quiescence induced by drug pressure or stationary phase, revealing global transcriptional reduction and specific upregulation of membrane and autophagy-related genes.

Microorganisms · Jan 3, 2022Peer-reviewedBioinformatics

Ecological divergence and hybridization of Neotropical Leishmania parasites

Frederik Van den Broeck, Nicholas Jon Savill, Hideo Imamura, Mandy J Sanders, Ilse Maes, Sinclair Cooper, David Mateus, Marlene Jara, Vanessa Adaui, Jorge Arévalo, Alejandro Llanos‐Cuentas, Lineth García, Elisa Cupolillo, Michael A. Miles, Matthew Berriman, , Jean‐Claude Dujardin

This study examines the evolutionary history and hybridization of Leishmania parasites using whole genome sequencing, revealing ecological divergence and genetic mosaic ancestry in hybrids.

Proceedings of the National Academy of Sciences · Sep 21, 2020Peer-reviewedGenomics