Achim C. Schnaufer

This study uses a genetic screen in Trypanosoma brucei to identify novel kDNA maintenance factors, validates one as a novel replication factor, and provides a prioritized list of candidates.

The paper identifies proteolytic processing of the F1-ATPase subunit α in Trypanosoma brucei, showing that cleavage occurs in the cytosol before mitochondrial import.

This paper identifies mutations in the gamma subunit of the mitochondrial ATP synthase in Trypanosoma brucei that lead to kinetoplast loss and drug resistance.

The paper shows TbTim20 is critical for protein import under low membrane potential in trypanosomes lacking mitochondrial DNA.

The paper identifies KREH2 helicase as a repressor of ND7 mRNA editing in T. brucei by modulating canonical and moonlighting gRNA utilization, revealing its dual role in developmental editing control.

This study shows that oxidative phosphorylation is essential for Trypanosoma brucei migration within tsetse flies but not for initial colonization.

The paper develops a high-content screen to identify inhibitors of mitochondrial DNA maintenance in trypanosomes and identifies a novel kDNA-targeting compound.

This study examines the evolutionary history and hybridization of Leishmania parasites using whole genome sequencing, revealing ecological divergence and genetic mosaic ancestry in hybrids.