Hideo Imamura

Transcriptional shift and metabolic adaptations during Leishmania quiescence using stationary-phase and drug pressure as models

The paper quantifies transcriptome and metabolome changes in Leishmania during quiescence induced by drug pressure or stationary phase, revealing global transcriptional reduction and specific upregulation of membrane and autophagy-related genes.

High throughput single-cell genome sequencing gives insights into the generation andevolution of mosaic aneuploidy in Leishmania donovani

The paper uses high throughput single-cell genome sequencing to study mosaic aneuploidy in Leishmania donovani, finding rapid karyotype changes and chromosome-specific adaptations.

Ecological divergence and hybridization of Neotropical Leishmania parasites

This study examines the evolutionary history and hybridization of Leishmania parasites using whole genome sequencing, revealing ecological divergence and genetic mosaic ancestry in hybrids.

Global genome diversity of the Leishmania donovani complex

The paper presents a comprehensive genome-wide study of Leishmania donovani complex isolates, revealing genetic diversity and structural variation across species and geographical regions.

Exploring the evolution and adaptive role of mosaic aneuploidy in a clonal Leishmania donovani population using high throughput single-cell genome sequencing

This paper uses high-throughput single-cell genome sequencing to analyze karyotype variation in a clonal Leishmania donovani population, revealing mosaic aneuploidy and its potential adaptive role.

Parallel sexual and parasexual population genomic structure in Trypanosoma cruzi

This study shows T. cruzi maintains sexual populations alongside clonal parasexual ones, with distinct genomic structures and reproductive modes.