Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brain
Rachel L. Kember, Rachel Vickers‐Smith, Heng Xu, Sylvanus Toikumo, Maria Niarchou, Hang Zhou, Emily E. Hartwell, Richard C. Crist, Christopher T. Rentsch, Million Veteran Program, Lea Karatheodoris Davis, Amy C. Justice, Sandra Sanchez‐Roige, Kyle Matthew Kampman, Joel E. Gelernter, Henry R. Kranzler
This study performs a cross-ancestry meta-analysis of opioid use disorder, identifying 14 loci, including 12 novel ones, and finding significant genetic correlations with psychiatric and neurological traits.
Nature Neuroscience · Sep 28, 2022Peer-reviewedGenetic & Genomic Medicine