Rachel Vickers‐Smith

Multi-ancestry Genome-wide Association Study of Inpatient Opioid Dosing Following Knee or Hip Arthroplasty

This study investigates genetic predictors of inpatient opioid exposure after knee or hip surgery using EHR and genotype data from 27,896 individuals across three ancestries, finding no genome-wide significant loci.

Genetic underpinnings of the transition from alcohol consumption to alcohol use disorder: shared and unique genetic architectures in a cross-ancestry sample

This study identifies genetic loci associated with alcohol use disorder and consumption, finding distinct genetic architectures and variants with direct effects on AUD.

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brain

This study performs a cross-ancestry meta-analysis of opioid use disorder, identifying 14 loci, including 12 novel ones, and finding significant genetic correlations with psychiatric and neurological traits.

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality

This study identifies 29 risk variants for problematic alcohol use through a large meta-analysis and explores its genetic relationships with other traits.

Genome-wide Association Study of Alcohol Consumption and Use Disorder in Multiple Populations (N = 274,424)

This study identifies 18 genome-wide significant loci for alcohol consumption and AUD, finds genetic overlap but also divergence, and highlights the role of central nervous system cells.