Laurent Malaquin

This paper develops interconnected macroporous GelMA scaffolds using temperature-controlled spinodal decomposition to optimize pore size for enhanced cell culture.

This study shows that goblet cells create tight junction fractures between enterocytes, increasing gut permeability under homeostatic conditions and during hypertrophy.

The paper introduces a human colon microphysiological system that replicates the 3D topography and matrix stiffness of the colon using hydrogels and microfluidic control, enabling long-term culture and imaging of colonic epithelial cells.