Author

Xue Deng

Chinese Academy of SciencesORCID 0009-0003-6112-0700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

Kai ZhangiD· 3 shared Yanshan FangiD· 3 shared Yongjia DuaniD· 3 shared Beituo Qian· 2 shared Cong LiuiD· 2 shared Gang Duan· 2 shared Jinge GuiD· 2 shared Qiangqiang WangiD· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersNeuroscience

Kai ZhangORCID

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3 papers

Recent·Most cited

NeuroscienceThe Journal of Cell BiologyPeer-reviewedOct 5, 2021

CHMP2B regulates TDP-43 phosphorylation and proteotoxicity via modulating CK1 turnover independent of the autophagy-lysosomal pathway

Xue Deng, Xing Sun, Wenkai Yue…·Yanshan Fang

This study identifies CHMP2B as a regulator of TDP-43 phosphorylation and proteotoxicity through CK1 turnover, independent of autophagy-lysosomal pathways in neurodegenerative diseases.

27 citations

Drosophilamouse

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NeuroscienceMolecular CellPeer-reviewedJul 9, 2020

Stress induces cytoprotective TDP-43 nuclear bodies through lncRNA NEAT1-promoted phase separation

Chen Wang, Yongjia Duan, Gang Duan…·Yanshan Fang

The paper shows stress induces TDP-43 nuclear bodies via NEAT1-promoted phase separation, which protects cells from toxicity and is disrupted by an ALS mutation.

231 citationstop 1%

humanDrosophila

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NeuroscienceCell ResearchPeer-reviewedFeb 6, 2019

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

Yongjia Duan, Aiying Du, Jinge Gu…·Yanshan Fang

This study shows PARylation regulates RNP granule dynamics and neurotoxicity of disease-related RNA-binding proteins, with PARP inhibition reducing neurotoxicity in ALS models.

277 citationstop 1%

Drosophilaexperimental assay

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