Ming Zhang

Spliformer-V2 predicts and interprets tissue-specific effects of splice-altering variants, identifying disease-relevant genes and therapeutic targets in ALS.

This paper shows C9orf72 expansions create a folate-sensitive fragile site FRA9A, leading to chromosomal instability and immune responses in patient cells and mice.

This study identifies circHMGCS1 as a regulator of vascular endothelial dysfunction in diabetes by sponging miR4521, leading to impaired nitric oxide production and increased oxidative stress.