Disruption of theta-timescale spiking impairs learning but spares hippocampal replay
Abhilasha Joshi, Alison E. Comrie, Samuel R. Bray, Abhijith Mankili, Jennifer A. Guidera, Rhino Nevers, Xulu Sun, Emily J. Monroe, Viktor Kharazia, Ryan Ly, Daniela Astudillo Maya, Denisse Morales-Rodriguez, Jai Y. Yu, Anna Kiseleva, Victor Perez, Loren M. Frank
This study shows that disrupting theta-timescale spiking during locomotion impairs learning but does not affect hippocampal replay during immobility in rats.
bioRxiv · Sep 15, 2025 · PreprintNeuroscience