Joshua D. Berke

This study reveals spatially organized dopamine dynamics in the nucleus accumbens core of mice, showing distinct patterns in anterior and posterior regions that do not align with canonical reward prediction error models.

This study shows that meta-learning in rats involves changes in prefrontal cortical dynamics that enable rule-based reward learning.

This study shows that dopamine neuron responses to food and water cues are modulated by internal state, with hunger-specific amplification of food cue responses.

The paper shows that parvalbumin interneurons restrain and shape striatal firing sequences during action execution in rats.

The paper analyzes the conservation and evolution of striatal interneurons across mammals, finding that TAC3 interneurons are conserved and that neuronal types evolve through redistribution and refinement.

The paper shows that cholinergic pauses and dopamine reward prediction errors differ across striatal subregions in rats during decision-making tasks.

The paper shows that rat hippocampus generates flexible representations of alternative spatial locations during navigation, modulated by changing cognitive demands.

The paper shows that blue light can falsely trigger dopamine release measurements using RdLight1, questioning previous findings on cholinergic interneurons' role in dopamine release.

This study shows that D1+ neurons in the nucleus accumbens fire more during reward expectation and trial initiation, while D2+ neurons respond more to reward delivery.

The paper shows dopamine signals in rats update value through two learning processes during foraging in a complex environment.

This study shows that cholinergic interneurons in the nucleus accumbens drive dopamine release, influencing motivated behavior in rats.

The paper examines how changes in basal ganglia output, specifically in the substantia nigra pars reticulata, contribute to self-restraint during a behavioral inhibition task in rats.

The paper shows dopamine signals in different striatal regions encode reward prediction errors over distinct time scales, supporting adaptive learning across behaviors.

The paper shows that sleep spindles during NREM sleep mediate corticostriatal plasticity, which is critical for the emergence of automatic behavior following training.

The paper shows that rats use GPe network states to strategically inhibit actions, with specific state-space locations predicting error types during behavioral inhibition.

The paper applies an improved statistical inference framework to neuroscience models, finding more accurate and sparse parameter estimates that reshape interpretations across multiple datasets.

The paper generates and validates two novel Cre-expressing rat lines for studying striatal pathways.

The paper generates and validates two knock-in rat strains expressing Cre or Flp recombinase under the Parvalbumin promoter for studying inhibitory interneurons.

The paper shows that dopamine release in forebrain regions correlates with reward expectation, while VTA dopamine cell firing shows error-like responses, suggesting distinct mechanisms for motivation signals.

The paper models transient beta oscillations in the basal ganglia using a computational model combined with experimental data from rats performing a task, showing they share mechanisms with pathological beta oscillations in Parkinson's disease.