ALS monocyte-derived microglia reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression.
Hazel Quek, Carla Cuní‐López, Romal Stewart, Tiziana Colletti, Antonietta Notaro, Yifan Sun, Christine Cong Guo, Michelle K. Lupton, Tam Hong Nguyen, Lotta E. Oikari, Tara Laurine Roberts, Yi Chieh Lim, Vincenzo La Bella, Anthony Robert White
This paper develops a method to generate monocyte-derived microglia from ALS patient blood, revealing functional impairments and pathological features associated with disease progression.
Journal of Neuroinflammation · Feb 28, 2022Peer-reviewedNeuroscience