Hazel Quek

This study identifies proteomic and transcriptomic changes in olfactory stem cells from AD and MCI patients, revealing pathway-level overlaps and potential biomarkers.

This study identifies regional and sub-regional microglial heterogeneity in the healthy mouse brain and retina using bulk and single-cell RNA sequencing.

This study examines how wildfire smoke and diesel exhaust affect inflammatory responses in aging human microglia, showing distinct temporal and molecular effects on oxidative stress and cytokine profiles.

This paper develops a patient-derived BBB model to screen copper bis(thiosemicarbazone) complexes for Alzheimer's disease treatment, identifying CuII(dtsm) as a promising candidate with improved BBB permeability and anti-inflammatory effects.

The paper uses olfactory cells from Alzheimer's patients to identify gene expression changes linked to cognitive decline.

This paper develops a method to generate monocyte-derived microglia from ALS patient blood, revealing functional impairments and pathological features associated with disease progression.

This study develops 3D models of Alzheimer's patient microglia that show distinct disease features and drug responses compared to 2D cultures.