D-lactate enhances inflammatory and cytotoxic functions of Th1 cells through stereospecific control of mitochondrial ROS
Adrian Madrigal-Avilés, Valerie Plajer, Paulo R. Viana Mendonca, Sebastian Serve, Leticia Soriano‐Baguet, Dirk Brenner, Maria R. Dzamukova, Mir‐Farzin Mashreghi, Max Löhning
This study identifies D-lactate's stereospecific role in enhancing Th1 cell cytotoxicity and inflammation through mitochondrial ROS regulation.
bioRxiv · Apr 3, 2025 · PreprintImmunology