Molecular BiologybioRxivPreprint
Epigenetically silencing gluconeogenic enzyme PCK1 by EZH2 promotes renal tubulointerstitial fibrosis
Ming Wu, Dong‐Ping Chen, Yanzhe Wang…·Chaoyang Ye
This study shows that EZH2 epigenetically suppresses PCK1, a gluconeogenic enzyme, promoting renal fibrosis, and that restoring PCK1 reduces fibrosis in CKD models.
2 citations