Lorraine O’Driscoll

Extracellular Vesicles-Mediated Crosstalk in Bone: miR-150-5p as a Mechanosensitive Inhibitor of Osteoclastogenesis

This study identifies mechanically-activated osteocyte-derived extracellular vesicles and miR-150-5p as key regulators of osteoclastogenesis and potential therapeutic targets for skeletal diseases.

Mechanically activated bone cell derived extracellular vesicles regulate angiogenesis in a manner that is dependent on the stage of lineage commitment

This study shows that mechanically activated osteocyte-derived extracellular vesicles enhance angiogenesis in a pre-clinical model, suggesting their potential as a pro-angiogenic nanotherapeutic for bone repair.

AGR2, a potential prognostic and predictive biomarker and therapeutic to overcome drug resistance in HER2-overexpressing cancer

This study identifies AGR2 as a prognostic biomarker and potential therapeutic target for overcoming drug resistance in HER2-overexpressing cancers.

Optimisation and comparison of orthogonal methods for separation and characterisation of extracellular vesicles to investigate how representative infant milk formula is of milk

This study compares methods to isolate and characterise extracellular vesicles from infant milk formula and skim milk, finding that formula-derived vesicles are compromised compared to milk.