Mechanically activated bone cell derived extracellular vesicles regulate angiogenesis in a manner that is dependent on the stage of lineage commitment
C.S. Martins, M. Maggio, Cansu Görgün, Mathieu Y. Brunet, Marko Dobricic, R. Almasri, Fergal J. O’Brien, Lorraine O’Driscoll, David A. Hoey
This study shows that mechanically activated osteocyte-derived extracellular vesicles enhance angiogenesis in a pre-clinical model, suggesting their potential as a pro-angiogenic nanotherapeutic for bone repair.
bioRxiv · Jul 29, 2025 · PreprintBioengineering