Long-term Tolerance to Islet Transplantation via Targeted Reduction of beta cell-specific T cells.
Michael Kotliar, Eileen E. Cianciolo, Duc Hung Pham, Kaitlin R. Carroll, Artem Barski, Michael B. Jordan, Jonathan D. Katz
This paper demonstrates that targeting islet-reactive T effector cells with a combination therapy improves long-term islet graft acceptance in T1D mice.
bioRxiv · Sep 2, 2024 · PreprintImmunology