PhysiologybioRxivPreprint
Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cycling
Justin H. Berger, Allison N. Lau, Larry C. James…·Daniel P. Kelly
This paper shows that deleting MondoA globally protects against diet-induced obesity by increasing energy expenditure through enhanced glucose uptake and glycolytic flux, leading to elevated glycerol synthesis and lipolysis.
DOI 10.1101/2025.10.06.680559