Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cycling
Justin H. Berger, Allison N. Lau, Larry C. James, Renee Taing, Byung Yong Ahn, Xiaofei Yin, Tomoya Sakamoto, Kirill Batmanov, Olivia Jordan, Jiten D. Patel, Jeffrey Zhou, Paul M. Titchenell, Brian N. Finck, Gregory J. Tesz, Daniel P. Kelly
This paper shows that deleting MondoA globally protects against diet-induced obesity by increasing energy expenditure through enhanced glucose uptake and glycolytic flux, leading to elevated glycerol synthesis and lipolysis.
bioRxiv · Oct 6, 2025 · PreprintPhysiology