Author

Frances E. Harris

Johns Hopkins UniversityORCID 0000-0002-7308-8619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:E. coli· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Approach:simulation· 1

Frequent Co-Authors

Jie XiaoiD· 3 shared Ao MaiD· 1 shared Boaz GoldbergiD· 1 shared Christopher H. BohreriD· 1 shared David J. HathcockiD· 1 shared Fenfei LengiD· 1 shared Hammad FarooqiD· 1 shared Hunter HendrixiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

Jie XiaoORCID

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3 papers

Recent·Most cited

Disentangling polymer confinement from specific-folding interactions reveals the drivers of E. coli chromosome organization

Pourya Delafrouz, Tanya Nesterova, Frances E. Harris, Hammad Farooq, Lin Du, Jing Liu, Ao Ma, Jie Xiao, J C Liang

The paper develops a polymer simulation framework to distinguish specific-folding interactions from polymer compaction in E. coli, revealing SFIs shape chromosome organization and gene expression.

bioRxiv · May 23, 2026 · PreprintGenomics

Repetitive extragenic palindrome (REP) elements are local, context-dependent, dual 3'UTR regulators in Escherichia coli

Frances E. Harris, Yanting Hu, Subhash Chandra Verma, Sankar L Adhya, Weiqiang Zhou, Jie Xiao

This study identifies REP elements as dual regulators of 3'UTR function in E. coli, controlling transcription termination and mRNA stability in a context-dependent manner.

bioRxiv · Mar 25, 2026 · PreprintBiophysics

Chromosomal Topological Domain Formation Modulates Transcription and the Coupling of Neighboring Genes in Escherichia coli

Nicolás N. Yehya, Christopher H. Bohrer, Qiwei Yu, David J. Hathcock, Boaz Goldberg, Siqi Leng, Frances E. Harris, Hunter Hendrix, Maxwell White, Fenfei Leng, Sam Meyer, Yuhai Tu, Jie Xiao

This study shows that chromosomal topological domains in E. coli repress transcription, reduce orientation effects, and modulate gene coupling through supercoiling changes.

bioRxiv · Nov 23, 2025 · PreprintBiophysics