This study shows planarians develop radiotolerance through repeated ionizing radiation exposure, maintaining genomic integrity and reproductive function.

bioRxiv · Oct 25, 2024 · PreprintDevelopmental Biology

The DNA Methyltransferase DMAP1 is Required for Tissue Maintenance and Planarian Regeneration

Salvador Rojas, Paul G. Barghouth, Peter Karabinis, Néstor J. Oviedo

This study investigates the role of DMAP1 in planarian regeneration and tissue maintenance, finding it essential for neoblast differentiation, DNA stability, and axial polarity.

Developmental Biology · Aug 23, 2024Peer-reviewedDevelopmental Biology

FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates

Paul G. Barghouth, Stavros Melemenidis, Pierre Montay‐Gruel, Jonathan Ollivier, Vignesh Viswanathan, Patrik Gonçalves Jorge, Luis Antonio Cruz Soto, Brianna C. Lau, Cheyenne Sadeghi, Anushka Edlabadkar, Richard Zhang, Ning Ru, Janet E. Baulch, Rakesh Manjappa, Jinghui Wang, , Richard L. Frock

This study shows FLASH-RT and CONV-RT produce similar levels and proportions of chromosome translocations and junction structures under various oxygen conditions.

Radiotherapy and Oncology · Nov 1, 2023Peer-reviewedMolecular Biology

Restoration of DNA Integrity and Cell Cycle by Electric Stimulation in Planarian Tissues Damaged by Ionizing Radiation

Devon Charles Cardoso Davidian, Melanie LeGro, Paul G. Barghouth, Salvador Rojas, Benjamin Ziman, Eli Isael Maciel, David H. Ardell, Ariel L. Escobar, Néstor J. Oviedo

Electric stimulation restores DNA integrity and cell cycle in planarian tissues damaged by ionizing radiation through Ca2+ signaling and stem cell activation.

Journal of Cell Science · Mar 24, 2022Peer-reviewedDevelopmental Biology