This study compares FLASH and conventional dose rate radiotherapy in a murine breast cancer model, finding comparable tumor control with FLASH achieving higher eradication rates at 30 Gy in small tumors.

Cancers · Mar 25, 2025Peer-reviewedCancer Biology

Rapid Sterilization of Clinical Apheresis Blood Products using Ultra-High Dose Rate Radiation

Stavros Melemenidis, Khoa D. Nguyen, Rosella Baraceros-Pineda, Cherie K. Barclay, Joanne Bautista, Hubert D. Lau, Muhammad Ramish Ashraf, Rakesh Manjappa, Suparna Dutt, Luis Antonio Cruz Soto, Nikita Katila, Brianna C. Lau, Vignesh Viswanathan, Amy S. Yu, Murat Sürücü, , Tho D. Pham

This paper demonstrates that rapid irradiation of blood products with ultra-high dose rates can effectively sterilize them against bacteria and viruses while preserving functional integrity.

International Journal of Molecular Sciences · Mar 7, 2025Peer-reviewedMicrobiology

FLASH-RT does not affect chromosome translocations and junction structures beyond that of CONV-RT dose-rates

Paul G. Barghouth, Stavros Melemenidis, Pierre Montay‐Gruel, Jonathan Ollivier, Vignesh Viswanathan, Patrik Gonçalves Jorge, Luis Antonio Cruz Soto, Brianna C. Lau, Cheyenne Sadeghi, Anushka Edlabadkar, Richard Zhang, Ning Ru, Janet E. Baulch, Rakesh Manjappa, Jinghui Wang, , Richard L. Frock

This study shows FLASH-RT and CONV-RT produce similar levels and proportions of chromosome translocations and junction structures under various oxygen conditions.

Radiotherapy and Oncology · Nov 1, 2023Peer-reviewedMolecular Biology