Richard L. Frock

This study identifies the role of ATM and 53BP1 in regulating alternative end joining-mediated V(D)J recombination by analyzing repair outcomes of RAG1/2-initiated DSBs.

This study shows DNA-PKcs inhibition increases chromosome translocations in human cells and shifts repair mechanisms toward MMEJ, similar to mice, highlighting its role in suppressing illegitimate rearrangements.

This study shows FLASH-RT and CONV-RT produce similar levels and proportions of chromosome translocations and junction structures under various oxygen conditions.

The paper shows that shifting the RNA:DNA hybrid relative to the PAM in SpCas9 generates DNA overhangs and accelerates complex dissociation after cleavage.

The paper shows that Ku70 suppresses alternative end-joining (A-EJ) in G1-arrested progenitor B cells, directing DSB repair toward classical nonhomologous end-joining (C-NHEJ) and preventing translocations.