Mechanisms of maternal antibody interference to rotavirus vaccination
Tawny L. Chandler, Sarah Woodyear, Valerie Chen, T. Lonergan, Natalie Baker, Katherine Harcourt, Simon Clare, Faraz Ahmed, Sarah Caddy
This study investigates how maternal antibodies interfere with rotavirus vaccination in neonates using a mouse model, finding that vaccine clearance rather than FcγRIIB signaling or epitope masking is the main mechanism of interference.
bioRxiv · Feb 26, 2025 · PreprintImmunology