Antibody treatment targeting nitrated alpha-synuclein counteracts protein spreading pathology
Ayşe Ulusoy, Sarah Wright, Pietro La Vitola, Katharina Klinger, Eugenia L. Harbachova, Angela Rollar, Xiang Xu, Anushka Takhi, Nathan Behrendt, Anthony Mastracci, Bryan Lewis, Valerie Chen, Harry Ischiropoulos, Sheerin K. Shahidi-Latham, Irene Griswold‐Prenner, Donato A. Di Monte
This study shows that targeting nitrated alpha-synuclein with an antibody reduces pathology in Parkinson's disease models and correlates with increased levels in Parkinson's patients.
bioRxiv · May 26, 2026 · PreprintNeuroscience