NeurosciencebioRxivPreprint
Aggregation promoting sequences rather than phosphorylation are essential for Tau-mediated toxicity in Drosophila
Amber S. Cooper, Bradley Richardson, Eva Ruiz…·Amritpal K. Mudher
This study shows that Tau aggregation, not phosphorylation, is critical for neurotoxicity in Drosophila, suggesting that targeting aggregation may be more effective than targeting phosphorylation in tauopathies.
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