This study examines interval timing deficits in Nrxn1+/- mice, a model of autism spectrum disorder, finding earlier timing responses compared to control mice.

Autism Research · Mar 20, 2026Peer-reviewedNeuroscience

The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy

Sabateeshan Mathavarajah, Sandhya Chipurupalli, Elias B. Habib, William D. Kim, Megan M. Aoki, Dale P. Corkery, Kennedy I.T. Whelan, Jordan Lukacs, Melis Erkan, Victor D. Martínez, Kevin S. Smith, Stephen B. Montgomery, Jayme Salsman, Robert J. Huber, Graham Dellaire

This study identifies a conserved PRP4K-CHMP4B/vps32 splicing circuit that regulates autophagy in both human cells and Dictyostelium discoideum.

Cell Reports · Jun 16, 2025Peer-reviewedCell Biology

PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates

Sabateeshan Mathavarajah, Kathleen L. Vergunst, Elias B. Habib, Shelby K. Williams, Raymond He, Maria Maliougina, Mika Park, Jayme Salsman, Stéphane Roy, Ingo Braasch, Andrew J. Roger, David N. Langelaan, Graham Dellaire

This study identifies PML and PML-like exonucleases as cytoplasmic suppressors of LINE-1 retrotransposition in jawed vertebrates, showing functional conservation across species.

Nucleic Acids Research · Feb 24, 2023Peer-reviewedMolecular Biology