Graham Dellaire

This study identifies a conserved PRP4K-CHMP4B/vps32 splicing circuit that regulates autophagy in both human cells and Dictyostelium discoideum.

This study shows that high telomeric SUMO levels promote APB nucleation and enhance ALT efficiency through BLM recruitment and DNA synthesis.

The paper identifies FTSJ3 as a critical vulnerability in hTERT-overexpressing cancers by showing its role in TERRA methylation and telomeric heterochromatin stability.

This study shows SUMO promotes DNA repair protein collaboration for telomere maintenance in ALT cancer cells without PML bodies.

This study identifies PML and PML-like exonucleases as cytoplasmic suppressors of LINE-1 retrotransposition in jawed vertebrates, showing functional conservation across species.

This paper introduces a marker-free co-selection strategy to enhance gene editing efficiency in human cells using CRISPR-Cas9 and Cpf1 systems.