Author

Séverine Morisset‐Lopez

Centre National de la Recherche ScientifiqueORCID 0000-0002-9930-7824Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Laetitia CobretiD· 2 shared Abdelmoumen KassoussiiD· 1 shared Alexander GastiD· 1 shared Amina ZahafiD· 1 shared Barbara Lecis· 1 shared Cédric RaouliD· 1 shared Chun-Lei ZhangiD· 1 shared Cyril GuimpiediD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Laetitia CobretORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 5, 2026

Dysregulation of LINGO1 expression in the SOD1(G93A) mutant mice during symptomatic stages of the disease and early postnatal oligodendrogenesis

Amina Zahaf, Julie Bourseguin, Laetitia Cobret…·Séverine Morisset‐Lopez

This study shows LINGO1 is upregulated in SOD1(G93A) mice during ALS progression and early oligodendrogenesis, with miR-138 downregulation, suggesting potential therapeutic targets for ALS.

DOI 10.64898/2026.09.03.749143

mousebulk RNA-seq

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NeuroscienceACS Chemical NeurosciencePeer-reviewedMay 29, 2026

TARGETING 5-HT7 RECEPTOR WITH BIASED LIGANDS TO ALLEVIATE PAIN AND SPINAL NEUROINFLAMMATION

Fahima Madouri, Cyril Guimpied, Enora Pigeon…·Séverine Morisset‐Lopez

This study compares two 5-HT7R biased ligands, Serodolin and MOA51, showing they reduce pain and spinal neuroinflammation without tolerance.

1 citation

mouseexperimental assay

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NeuroscienceMolecular PsychiatryPeer-reviewedOct 4, 2024

Missense mutation in the activation segment of the kinase CK2 models Okur Chung neurodevelopmental disorder and alters the hippocampal glutamatergic synapse

Jose Manuel Cruz-Gamero, Demetra Ballardin, Barbara Lecis…·Heike Rebholz

This paper creates a knockin mouse model with a K198R mutation in CK2 kinase, showing ASD-like behaviors and synaptic deficits, validating it as a model for Okur-Chung Neurodevelopmental Syndrome.

6 citations

mouseexperimental assay

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