Intermolecular interactions of CYP3A enzymes and cytosolic sulfotransferases (SULT1E1, SULT2A1)
Anastasiya Tumilovich, Evgeniy O. Yablokov, Oksana V. Gnedenko…·Alexis S. Ivanov
This study identifies direct physical interactions between CYP3A4/3A5 and SULT1E1/2A1 using SPR, activity assays, and AlphaFold2 modeling, revealing potential substrate channeling mechanisms.