Capturing Cardiomyocyte Cell-to-Cell Heterogeneity via Shotgun Single Cell Top-Down Proteomics
Fábio Pereira Gomes, Blandine Chazarin, Aleksandra Binek, Aleix Navarro Garrido, Kenneth R. Durbin, Ricard Garcia‐Carbonell, Kanchan Pathak, Delaynie Brinkman, Reynaldo Magalhães Melo, Anja Karlstaedt, Enrique Sáez, Jennifer E. Van Eyk, John R. Yates
This study introduces a shotgun single-cell top-down proteomics method to profile proteoform diversity in cardiomyocytes, revealing significant molecular heterogeneity across individual cells.
bioRxiv · Mar 28, 2026 · PreprintCell Biology