Author

Fabrizio Benedetti

Centre Hospitalier Universitaire VaudoisORCID 0000-0002-9959-9142Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Aspram MinasyaniD· 2 shared Bovannak Stewen ChapiD· 2 shared David BarrasiD· 2 shared Denarda Dangaj LanitiiD· 2 shared Eleonora GhisoniiD· 2 shared Flavia De Carlo· 2 shared George CoukosiD· 2 shared Jose Ramon Conejo-GarciaiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

Aspram MinasyanORCID

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2 papers

Recent·Most cited

Actionable spatial prostanoid barriers constrain BiTE-driven adoptive T cell immunity in intact human tumors

Bovannak Stewen Chap, Tania Santoro, Paris Kosti, David Barras, Noémie Fahr, Mathieu Desbuisson, Fabrizio Benedetti, Aspram Minasyan, Asia Andreoli, E. Ghisoni, Flavia De Carlo, Khadidja Benkortbi, Apostolos Sarivalasis, Chahin Achtari, Delfyne Hastir, , Denarda Dangaj Laniti

The paper uses patient-derived explants to study BiTE-driven T cell responses in tumors, identifying the COX/PGE2 axis as a barrier to immune activation and showing COX inhibition enhances anti-tumor effects.

bioRxiv · Mar 30, 2026 · PreprintSystems Biology

Myeloid cell networks determine reinstatement of original immune environments in recurrent ovarian cancer

Eleonora Ghisoni, Fabrizio Benedetti, Aspram Minasyan, Mathieu Desbuisson, Paula Cunnea, Alizée J Grimm, Noémie Fahr, Charlotte Capt, Nicolas Rayroux, Flavia De Carlo, D. C. Gulhan, Julien Dagher, David Barras, Matteo Morotti, Juan A. Marín‐Jiménez, , Denarda Dangaj Laniti

The paper identifies immune phenotypes and myeloid cell networks in recurrent ovarian cancer that influence prognosis and immune environment reinstatement.

Cancer Cell · Jul 31, 2025Peer-reviewedImmunology