Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells
Tomasz M. Grzywa, Alexandra Neeser, Ranjani Ramasubramanian, Anna M. Romanov, Ryan Tannir, Naveen K. Mehta, Benjamin James Cossette, Duncan M. Morgan, Beatriz Goncalves, Ina Sukaj, Elisa Bergaggio, Stephan Kadauke, Regina M. Myers, Luca Paruzzo, Guido Ghilardi, , Darrell J. Irvine
This study develops a method to generate optimized peptide ligands for CAR-T cell restimulation, demonstrating enhanced expansion and memory development in preclinical models.
Nature Biomedical Engineering · Aug 25, 2025Peer-reviewedBioengineering