Author

Beatriz Goncalves

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Aditya Bharti· 1 shared Alexander Chan Chi HuangiD· 1 shared Alfie J Hall· 1 shared Anita Valand· 1 shared Bin LiuiD· 1 shared Carl H. JuneiD· 1 shared Catherine McMullan· 1 shared Colleen B. MaxwelliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperImmunology

Aditya Bharti

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Loss of PKN2 drives fibroblast reprogramming and extracellular matrix remodelling in pulmonary fibrosis

Catherine McMullan, Oscar A Peña, Poojitha Rajasekar, Anita Valand, Panayiota Stylianou, Gill Elliott, Molly Whitfield, Mathuscha Ratnasingham, Sahana Narayan, Alfie J Hall, Beatriz Goncalves, Vijay Mistry, Liesl Carr, Hilary Marshall, Bin Liu, , Katy Morgan Roach

This study shows that loss of PKN2 leads to fibroblast reprogramming and ECM remodelling in pulmonary fibrosis by altering key pathways and secretion.

bioRxiv · Sep 3, 2026 · PreprintCell Biology

Rapid Assessment of Immune Effector Cell-mediated Cytotoxicity using mRNA Lipid Nanoparticles

Philip Mollica, Jian Li, Sang-Hoon Kim, Beatriz Goncalves, Y Chen, Aditya Bharti, Dillon O'Neill, Evan W. Weber, M Alameh, Leyuan Ma

This paper introduces an mRNA-LNP method to assess immune effector cell-mediated cytotoxicity, showing it is rapid, consistent, and compatible with diverse tumor models.

Frontiers in Immunology · May 11, 2026Peer-reviewedImmunology

DR5 CAR-T cells target solid tumors and suppress MDSCs with minimal toxicity

Huaishan Wang, Shujing Liu, Prithvi Sinha, Fang Liu, Xiaogang Zhang, Yeye Guo, Beatriz Goncalves, Qiuxiang Zheng, Haiwei Mou, Jingbo Yang, Lili Huang, John Scholler, Fei Miao, Tingting Zeng, Giorgos Constantine Karakousis, , Xiaowei Xu

This study develops DR5-targeted CAR-T cells that kill solid tumors and MDSCs, enhance CD8+ T cell activity, and show minimal toxicity in preclinical models.

bioRxiv · Jun 9, 2025 · PreprintCancer Biology