Author

David S. Johnson

GigaGen (United States)ORCID 0000-0002-9967-9812Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

David S. Johnson1 paper · Columbia University Irving Medical Center

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

Savreet K. SandhuiD· 2 shared Adam S. AdleriD· 1 shared Alyssa Amezquita· 1 shared B BernsteiniD· 1 shared Chad NusbaumiD· 1 shared Clifford A. MeyeriD· 1 shared Eamon F.X. ByrneiD· 1 shared Erica Lyn StoneiD· 1 shared

Activity by Year

2012-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

Savreet K. SandhuORCID

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Author profile →

3 papers

Recent·Most cited

Discovery and Validation of Alternatives to VSV-G for Pseudotyping of Lentiviral Vectors for In Vivo Delivery of Anti-Tumor Transgenes

Matthew J. Spindler, Alyssa Amezquita, Eamon F.X. Byrne, R. C. Edgar, S. S. Ravi, Savreet K. Sandhu, T. Weller, David S. Johnson

The paper identifies and validates an alternative to VSV-G for lentivector pseudotyping to improve in vivo T cell transgene delivery for tumor therapy.

bioRxiv · Mar 3, 2025 · PreprintCancer Biology

Single cell transcriptomics reveals the effect of PD-L1/TGF-β blockade on the tumor microenvironment

Yoong Wearn Lim, Garry L. Coles, Savreet K. Sandhu, David S. Johnson, Adam S. Adler, Erica Lyn Stone

The paper uses single-cell RNA sequencing to study how PD-L1 and TGF-β blockade affect the tumor microenvironment, finding upregulated immune response genes and downregulated extracellular matrix genes.

BMC Biology · May 24, 2021Peer-reviewedGenomics

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang, Tao Liu, Clifford A. Meyer, Jérôme Eeckhoute, David S. Johnson, B Bernstein, Chad Nusbaum, R Myers, Myles A Brown, Wei Li, X. Shirley Liu

MACS calls ChIP-Seq peaks by estimating tag shift from Watson/Crick strand offsets and testing enrichment against a locally adaptive Poisson background, improving specificity and binding-site resolution.

Genome biology · Sep 17, 2008Peer-reviewedBioinformatics✦ In-depth digest