The paper identifies hormone-specific neuronal circuits in the hypothalamus that regulate sex- and state-dependent infant caregiving behaviors in mothers and fathers.

bioRxiv · Dec 12, 2025 · PreprintNeuroscience

Sensory Input, Sex, and Function Shape Hypothalamic Cell Type Development

Harris S. Kaplan, Brandon L. Logeman, Kai Zhang, Tate A. Yawitz, Celine Santiago, Noor Sohail, Mustafa Talay, Changwoo Seo, Serhiy Naumenko, Shannan J. Ho Sui, David D. Ginty, Bing Ren, Catherine G. Dulac

The paper examines how sensory input, sex, and function influence the developmental trajectories of hypothalamic cell types during early life transitions.

Nature · Mar 5, 2025Peer-reviewedNeuroscience

A Hypothalamic Circuit Underlying the Dynamic Control of Social Homeostasis

Ding Liu, Mostafizur Rahman, Autumn Johnson, Ryunosuke Amo, Iku Tsutsui‐Kimura, Zuri A. Sullivan, Nicolai Pena, Mustafa Talay, Brandon L. Logeman, Samantha Finkbeiner, Lechen Qian, Seungwon Choi, Athena Capo-Battaglia, Ishmail Abdus-Saboor, David D. Ginty, , Catherine G. Dulac

Opposing glutamatergic MPN Isolation and mostly GABAergic MPN Reunion neurons in the mouse preoptic hypothalamus encode social need and satiety, with touch as a likely cue.

Nature · Feb 26, 2025Peer-reviewedNeuroscience✦ In-depth digest

Evaluating single-cell cluster stability using the Jaccard similarity index

Ming Tang, Yasin Kaymaz, Brandon L. Logeman, Stephen W. Eichhorn, Zhengzheng Liang, Catherine G. Dulac, Timothy B. Sackton

The paper introduces tools to evaluate single-cell clustering stability using subsampling and the Jaccard similarity index, with an R package and Snakemake workflow for implementation.

Bioinformatics · Nov 2, 2020Peer-reviewedBioinformatics