Iku Tsutsui‐Kimura

This study shows that dopamine dynamics in the tail of the striatum are crucial for adapting to aversive stimuli and indirectly support appetitive learning.

The paper shows that dopamine and direct/indirect pathway neurons in the tail of the striatum regulate threat avoidance at different stages of learning.

Opposing glutamatergic MPN Isolation and mostly GABAergic MPN Reunion neurons in the mouse preoptic hypothalamus encode social need and satiety, with touch as a likely cue.

The paper uses machine learning to analyze novelty-induced behaviors and finds that dopamine in the striatum correlates with individual variability and is explained by a reinforcement learning model of threat prediction.

The paper shows dopamine axon activity in three striatal regions is similar but differs in reward response bias, which relates to habit and skill.

This study demonstrates that ramping dopamine signals correspond to reward prediction errors rather than state values, unifying rapid phasic and slow ramping signals as derivative-like computations.