Author

Daniel Lesman

Broad InstituteORCID 0000-0002-9982-7344Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Fei CheniD· 2 shared Haiqi CheniD· 2 shared Andrew EarliD· 1 shared Anisha LaumasiD· 1 shared Anubhav SinhaiD· 1 shared Bradley Robert CairnsiD· 1 shared C. Yan ChengiD· 1 shared Evan M. MurrayiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenomics

Fei ChenORCID

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2 papers

Recent·Most cited

Photoselective sequencing: microscopically-guided genomic measurements with subcellular resolution

Sarah M. Mangiameli, Haiqi Chen, Andrew Earl, Julie A. Dobkin, Daniel Lesman, Jason Daniel Buenrostro, Fei Chen

The paper introduces Photoselective Sequencing, a method to measure genomic data with subcellular resolution, and applies it to study chromatin accessibility and nuclear positioning in mouse brain cells.

Nature Methods · Apr 27, 2023Peer-reviewedGenomics

Dissecting Mammalian Spermatogenesis Using Spatial Transcriptomics

Haiqi Chen, Evan M. Murray, Anubhav Sinha, Anisha Laumas, Jilong Li, Daniel Lesman, Xichen Nie, Jim Hotaling, Jingtao Guo, Bradley Robert Cairns, Evan Z. Macosko, C. Yan Cheng, Fei Chen

This study uses spatial transcriptomics to create a spatial atlas of testis gene expression, identifying spatially segregated spermatogonial populations and disruptions in diabetic testes.

Cell Reports · Nov 1, 2021Peer-reviewedGenomics