Author

Xichen Nie

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Bradley Robert CairnsiD· 3 shared Jingtao GuoiD· 2 shared Anisha LaumasiD· 1 shared Annika Missel· 1 shared Anubhav SinhaiD· 1 shared Artur MayerhoferiD· 1 shared Benjamin R. EmeryiD· 1 shared C. Yan ChengiD· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMolecular Biology

Bradley Robert CairnsORCID

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3 papers

Recent·Most cited

Establishment of Developmental Gene Silencing by Ordered Polycomb Complex Recruitment in Early Zebrafish Embryos

Graham Hickey, Candice L. Wike, Xichen Nie, Yixuan Guo, Mengyao Tan, Patrick J. Murphy, Bradley Robert Cairns

The paper shows how developmental gene silencing is established in zebrafish embryos through H2Aub1 deposition by Rnf2-PRC1, followed by Aebp2-PRC2 recruitment and H3K27me3 deposition.

eLife · Jan 4, 2022Peer-reviewedMolecular Biology

Dissecting Mammalian Spermatogenesis Using Spatial Transcriptomics

Haiqi Chen, Evan M. Murray, Anubhav Sinha, Anisha Laumas, Jilong Li, Daniel Lesman, Xichen Nie, Jim Hotaling, Jingtao Guo, Bradley Robert Cairns, Evan Z. Macosko, C. Yan Cheng, Fei Chen

This study uses spatial transcriptomics to create a spatial atlas of testis gene expression, identifying spatially segregated spermatogonial populations and disruptions in diabetic testes.

Cell Reports · Nov 1, 2021Peer-reviewedGenomics

Single-Cell Analysis of Human Testis Aging, and Impact of Elevated Body Mass Index

Xichen Nie, Sarah K. Munyoki, Meena Sukhwani, Nina Schmid, Annika Missel, Benjamin R. Emery, Donor Connect, Jan‐Bernd Stukenborg, Artur Mayerhofer, Kyle E. Orwig, Kenneth Ivan Aston, James Morris Hotaling, Bradley Robert Cairns, Jingtao Guo

This study uses single-cell RNA-seq to analyze age-related changes in human testis and finds that dysregulation correlates with BMI in older men.

bioRxiv · Oct 19, 2021 · PreprintDevelopmental Biology