Author

Philippe Lanotte

Université de ToursORCID 0000-0002-9993-5548Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Arnaud FironiD· 2 shared Elise JacquemetiD· 2 shared Odile SismeiroiD· 2 shared Rachel LegendreiD· 2 shared Adeline PastuszkaiD· 1 shared Ariadna Hernandez Montoya· 1 shared Asmaa TaziiD· 1 shared Aymane Sadouni· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersMicrobiology

Arnaud FironORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Virulence regulates and boosts CRISPR-Cas9 immunity in Group B Streptococcus

Adeline Pastuszka, Maria-Vittoria Mazzuoli, Chiara Crestani, Léonie Deborde, Odile Sismeiro, Coralie Lemaire, Vanessa Rong, Myriam Gominet, Elise Jacquemet, Rachel Legendre, Philippe Lanotte, Arnaud Firon

This study shows that CovR, a virulence regulator, enhances CRISPR-Cas9 immunity in Group B Streptococcus by modulating Cas9 activity and improving immune memory.

Nature Communications · Jul 1, 2025Peer-reviewedMicrobiology

In-host evolution of Yersinia enterocolitica during a chronic human infection

Cyril Savin, Pierre Lê-Bury, Julien Guglielmini, Thibaut Douché, Guillem Mas Fiol, Rodolphe Buzelé, Cécile Le Brun, Frédéric Bastides, Maud François, Béatrice Birmelé, Laura Guichard, Julien Madej, Rémi Beau, Nicolas Cabanel, Laurent Dortet, , Javier Pizarro‐Cerdá

This study tracks genetic and phenotypic changes in Yersinia enterocolitica during a chronic human infection, revealing host-adaptive mutations and antibiotic resistance mechanisms.

Nature Communications · Jul 1, 2025Peer-reviewedMicrobiology

Coordinated regulation of osmotic imbalance by c-di-AMP shapes beta-lactam tolerance in Group B Streptococcus

Terry Brissac, Cécile Guyonnet, Aymane Sadouni, Ariadna Hernandez Montoya, Elise Jacquemet, Rachel Legendre, Odile Sismeiro, Patrick Trieu‐Cuot, Philippe Lanotte, Asmaa Tazi, Arnaud Firon

This study identifies c-di-AMP's role in beta-lactam tolerance in Group B Streptococcus by coordinating osmotic regulation and cell envelope stress responses.

microLife · Jan 1, 2024Peer-reviewedMicrobiology