Rachel Legendre

The paper identifies an epigenetic mechanism in bronchial epithelial cells that enables trained immunity through chromatin remodeling and gene expression changes following flagellin exposure.

This study shows that the K-D-K-E motif in RABV L protein's methyltransferase domain is crucial for immune evasion by altering viral and host RNA methylation, increasing sensitivity to interferon, and reducing pathogenicity.

This study identifies a cytochrome P450 gene variant that influences dengue virus susceptibility in Aedes aegypti mosquitoes.

This study shows that CovR, a virulence regulator, enhances CRISPR-Cas9 immunity in Group B Streptococcus by modulating Cas9 activity and improving immune memory.

This study identifies two-component regulatory networks in Streptococcus agalactiae by activating histidine kinases to reveal connections between regulatory systems and their roles in pathogenicity and cell envelope homeostasis.

This study identifies Prosaposin as a regulator of neural stem cell quiescence in zebrafish, showing it maintains deep quiescence and reduces activation.

This study identifies c-di-AMP's role in beta-lactam tolerance in Group B Streptococcus by coordinating osmotic regulation and cell envelope stress responses.

This study examines how maternal parity affects gene expression in Day 8 equine embryos, finding limited gene changes but significant pathway alterations in trophoblast and inner-cell-mass cells.

sgDI-tector detects and quantifies subgenomic RNAs in SARS-CoV-2 NGS data, identifying a ranked set of sgRNAs and comparing their levels to defective interfering viral genomes.

The study examines how maternal parity affects Day 8 embryo gene expression in old mares, finding altered gene expression related to nutrient exchange and environmental response.

ChIPflow is a pipeline for epigenomic data analysis from raw data to differential analysis, showing that statistical settings affect results depending on chromatin factor dynamics and variability.

The paper identifies HP1γ's RNA binding activity in transcribed genes and shows it enhances splicing fidelity by tethering pre-mRNA to chromatin through intronic repeats.

Sequanix provides a graphical interface for Snakemake workflows to make them more accessible to a broader audience.